ECTOINE
ECTOINE
CAS: 96702-03-3
Molecular Formula: C6H10N2O2
ECTOINE - Names and Identifiers
ECTOINE - Physico-chemical Properties
| Molecular Formula | C6H10N2O2 |
| Molar Mass | 142.16 |
| Density | 1.37 |
| Melting Point | ~280° |
| Boling Point | 381.5±35.0 °C(Predicted) |
| Storage Condition | Room Temprature |
| MDL | MFCD03419286 |
| Use | Ectoin has the function of moisturizing and repairing, and is widely used in the field of skin care products, and can be used to improve skin color. |
ECTOINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
ECTOINE - Nature
| melting point | ~280° |
| specific rotation | D20 140° (c = 1.0 in methanol) |
| boiling point | 381.5±35.0 °C(Predicted) |
| density | 1.37 |
| storage conditions | Sealed in dry,2-8°C |
| solubility | methanol: 20 mg/mL, clear, colorless |
| acidity coefficient (pKa) | 3.14±0.20(Predicted) |
| BRN | 7288977 |
| InChIKey | WQXNXVUDBPYKBA-YFKPBYRVSA-N |
Last Update：2024-04-09 19:55:45
ECTOINE - Introduction
| overview | Icodoin is also called tetrahydromethylpyrimidine carboxylic acid. Ikedoin protects halophilic bacteria from harm. It has two major functions: 1) Moisturizing: It is an important substance to maintain osmotic pressure balance. Its unique molecular structure has a strong water molecule complexation ability, which can make cells The free water inside is structured and is a very excellent natural moisturizer. 2) Repair: Ikedoin can resist the damage of ultraviolet rays to the skin and repair the cell DNA damage caused by ultraviolet rays. |
| source | The chemical formula of Ecodoin (Ectoine) is 2-methyl -1,4,5,6,-tetrahydropyrimidin-4-carboxylic acid, also known as tetrahydropyrimidine, is a new type of water-soluble zwitterionic amino acid derivative discovered in 1985. In 1985, Galinski first identified and isolated ectoine in halophilic bacteria by nuclear magnetic resonance and mass spectrometry. At high salt concentration, Ectoine, as a pressure compensation solute, accumulates in large quantities in some halophilic bacteria to resist changes in high osmotic pressure in the external environment. |
| efficacy and function | Icodoin is a natural and effective cosmetic active ingredient. Because it has a wide range of cell protection functions, it can be applied to cosmetics with many different functions. Ectoine has the functions of moisturizing, anti-oxidation, protection against photoaging, sun protection, etc. Good moisturizing Pretreatment of skin with Ecodoin can reduce skin damage caused by dehydration. One molecule of Ectoine can 4. five water molecules to structure free water in cells. Compared with glycerin, the skin is more moisturizing. Relevant data show that the Ectoine can continuously improve the skin's moisturizing and water-holding capacity during the application period, and the skin's water-holding capacity will not immediately decrease after stopping. After stopping for one week, the skin's water-holding capacity is still higher than that of the control group. Antioxidant effect Some clinical trials have shown that Ecodoin can prevent the weakening of the antioxidant capacity of cells with the increase of age, and has a certain antioxidant capacity. Experimental data show that the mixed use of 0.1mMEctoine, 0.5mM merthionine and 1.5mM mannitol can reduce the DNA single strand break of human glial cells under 400-800nm light source, reduce the intensity of ROS oxidation reaction, and thus reduce the oxidative damage of light to skin. Protection of immune system Langerhans cells (Langerhans cells) in the epidermis play a key role in the skin immune system, but they are very sensitive to ultraviolet pressure. The Ectoine can prevent the number of Langerhans cells from being reduced due to ultraviolet radiation, so that the skin's immune system can maintain normal functioning. Protection against light aging and sun protection Skin aging is not only the result of time, one of the important external factors is ultraviolet rays, especially UVA(320-400nm). In the entire ultraviolet band, the longest UVA wavelength has the lowest energy, but unlike UVB, the change of UVA content in sunlight is little affected by latitude, time period, weather and season, so the daily and annual UVA exposure dose is almost fixed and accumulates in large quantities throughout our lives. |
Last Update：2024-04-09 19:55:45
ECTOINE - Preparation
At present, Ecodoin (Ectoine) is mainly extracted from halophilic bacteria strains. An industrial technology for the production of tetrahydropyrimidine by halophilic bacteria has been established. This technology uses high concentration of glycerol as a carbon source. A process called "bacterial milking" is used to produce.
The "bacterial milking" process is that halophilic bacteria strains grow and multiply in high-concentration (such as 100g/L) salt culture solution, and the Ectoine is used as a pressure compensation solute to accumulate in a large amount in some halophilic bacteria to resist changes in high osmotic pressure in the external environment. When the cell concentration reaches the highest, the salt concentration suddenly drops from a high concentration (such as 100g/L) to a low concentration, when stimulated by hypotonic, bacteria can instantly release Ectoine accumulated in cells to the outside world to avoid cell expansion or fragmentation caused by the reduction of environmental osmotic pressure. Finally, it can be further purified through filtration, crystallization and other technologies to obtain Ectoine.
Literature shows that with the above method, it is possible to obtain about 2g Ectoine per liter of culture solution per day.
Last Update：2024-04-09 19:55:45
ECTOINE - Use
ECTOINE is a natural protective molecule called exogen that can help cells adapt and protect themselves in various extreme environments.
Detergent: ECTOINE has good surface activity and can reduce surface tension, so it can be used as a softener and anti fading agent for detergents.
Last Update：2024-04-09 19:55:45
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View History
ECTOINE
3Α-羟基-6K-5Β-胆甾烷-24-酸
5-BETA-ANDROSTAN-17-BETA-OL-3-ONE HEMISUCCINATE
2-Chlorothiophene
207569-11-7
双丙酮-D-甘露糖
FMOC-L-PHE-OH
(25,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
3Α-羟基-6K-5Β-胆甾烷-24-酸
5-BETA-ANDROSTAN-17-BETA-OL-3-ONE HEMISUCCINATE
2-Chlorothiophene
207569-11-7
双丙酮-D-甘露糖
FMOC-L-PHE-OH
(25,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID